On-slide Preparation of Caenorhabditis elegans Towards Quantitative, High-Resolution LA-ICP-TOF Mass Spectrometry Imaging
Aidan J. Reynolds, Aaron C. Sue, Keith W. MacRenaris, Thomas V. O’Halloran, Tian Autumn Qiu
This paper develops a workflow for high-resolution metal imaging in C. elegans using LA-ICP-TOF-MS, achieving 2-m spatial resolution with optimized embedding and ablation techniques.
Analytical Chemistry · Sep 17, 2026Peer-reviewedBiochemistry