Aaron C. Sue

This paper develops a workflow for high-resolution metal imaging in C. elegans using LA-ICP-TOF-MS, achieving 2-m spatial resolution with optimized embedding and ablation techniques.

The paper functionally screens ZIP8 variants to identify pathogenic mutations and trafficking defects using a combined experimental and computational approach.

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

This study shows that AIRE deficiency causes epididymitis and male infertility through immune-mediated fibrosis, iron deposition, and metal imbalance leading to sperm DNA damage.

AutoSpect automates LA-ICP-TOF-MS data processing, addressing drift correction and peak deconvolution to enable accurate elemental mapping and isotopic analysis.