Author

Lei Lü

Chinese Academy of Medical Sciences & Peking Union Medical CollegeORCID 0000-0002-7256-5583Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Boyi CheniD· 1 shared Chun Li· 1 shared Haodong GuoiD· 1 shared Hongyang Guo· 1 shared Qiaoling Shangguan· 1 shared Shangxun Zhao· 1 shared Shaopeng Sun· 1 shared Shuai XuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Boyi ChenORCID

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1 paper

Recent·Most cited

In vivo-compatible spatial multi-omics via hydrogen peroxide-independent APEX2 labeling

Boyi Chen, Hongyang Guo, Zhijian Yan, Wenjie Lu, Chun Li, Shuai Xu, Yanling Zhang, Haodong Guo, Shaopeng Sun, Xuege Sun, Shangxun Zhao, Qiaoling Shangguan, Yidong Chen, Lei Lü, Zhaofa Wu, , Wei Qin

This paper introduces Hi-APEX, a H2O2-independent APEX2 variant for in vivo spatial multi-omics, showing improved performance in capturing redox-sensitive processes and enabling in vivo applications.

Nature Chemical Biology · Oct 29, 2026Peer-reviewedBiochemistry