Wei Qin

This paper introduces Hi-APEX, a H2O2-independent APEX2 variant for in vivo spatial multi-omics, showing improved performance in capturing redox-sensitive processes and enabling in vivo applications.

This paper designs a new proximity labeling enzyme, FlexID, using computational methods to improve spatial precision and versatility for mapping protein interactions and proteomes.

This paper introduces RTPP to identify RNA-regulated proteins and generates a tissue-specific atlas of RNA-protein interactions, revealing novel orphan proteins and organ-specific dysregulation in Alzheimer's disease.

This paper introduces GZL626, a novel AR degrader that targets the N-terminal domain and RNF213-UBE2J2 complex, effectively degrading AR and AR-V7 and showing antitumor and antiviral activity.

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

The paper introduces Phase-APEX2, a method to specifically label membrane-less organelles, revealing their core components and molecular mechanisms.

This paper introduces SeeID, a near-infrared light-controlled proximity labeling method for studying dynamic protein interactomes in vitro and in vivo, revealing proteasome association with Parkin during mitophagy.

This paper introduces TyroID, an in vivo-compatible method for high-resolution mapping of extracellular proteomes, validated through applications in tumor xenografts and live mouse brains.

The paper introduces APEX-PS to map RNA binding proteins in cellular compartments, identifying SYNJ2BP as a mitochondrial mRNA anchor that aids stress recovery.