Steric control of signaling bias in the immunometabolic receptor GPR84
Pinqi Wang, Xuan Zhang, Akim Abdul Guseinov, Laura Jenkins, Carl von Hallerstein, Jonathan D. Colburn, Rowan Ives, Vincent B. Luscombe, Sara Marsango, Listiana Oktavia, Arun Raja, David R. Greaves, Philip Charles Biggin, Graeme Milligan, Cheng Zhang, , Angela J. Russell
The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.
Nature Communications · Sep 5, 2026Peer-reviewedPharmacology & Toxicology