Angela J. Russell

This study identifies Cn-alkylpyrones as endogenous agonists for GPR84, linking fatty acid biosynthesis derailment to pro-inflammatory signaling through KR inhibition.

This paper identifies a helix 8-proximate allosteric site in GPR84 and shows how it enables Gi-biased signalling through structural and dynamic mechanisms.

The paper identifies ligands with varying steric profiles that exhibit different β-arrestin recruitment capacities at GPR84, revealing a mechanism for controlling signaling bias.

This study shows that degrading LMO2 in T cell leukemia leads to loss of its DNA-binding partners and apoptosis, suggesting therapeutic potential for LMO2-targeting drugs.

The paper shows HDAC inhibitors induce AML cell differentiation via two distinct mechanisms: one through G1 arrest and another through G2 arrest via Aurora A and GSK3 inhibition.

This study identifies a small molecule, OXS-N1, that increases adult neurogenesis and improves memory in a mouse model of Alzheimer's disease through an in vitro phenotypic screen.