Romain Hamelin

The paper develops a low-input spatial proteomics workflow using standard lab equipment, achieving deep proteome coverage of the choroid plexus across age and sex in mice.

This study identifies FIKK1 as a kinase that phosphorylates VAR2CSA, enhancing its binding to CSA and promoting placental malaria virulence.

The paper identifies a noncanonical role for KZFPs in restricting TE-derived regulatory elements to maintain cell-type identity, independent of TRIM28.

This study uses proteomics to analyze Drosophila hemolymph after bacterial infection, identifying new proteins and changes in mitochondrial respiration.

This study identifies Casein Kinase 2 as the kinase responsible for phosphorylating VAR2CSA, enhancing its CSA binding and infected erythrocyte adhesion.

This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.

The paper maps organ-specific electrophile responsivity in C. elegans, identifying proteins that respond to reactive metabolites in a tissue-specific manner.

Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.