This paper develops a combined TIRF and 3D super-resolution microscopy platform to study the nanoscopic spatial organization of adhesion molecules on microvilli during cell rolling.

bioRxiv · Aug 26, 2025 · PreprintBiophysics

PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages

Amit Kumar Subudhi, Judith L. Green, Rohit Satyam, Todd Lenz, Rahul P. Salunke, Muhammad Shuaib, Ioannis Isaioglou, Steven Abel, Mohit Kumar Gupta, Luke E. Esau, Tobias Mourier, Raushan Nugmanova, Sara Mfarrej, Rupali Shivapurkar, Zenaida S Stead, , Arnab Pain

This study identifies PfAP2-MRP as a master regulator controlling parasite growth, chromatin structure, and var gene expression during malaria parasite blood stages.

bioRxiv · May 23, 2023 · PreprintGenomics

Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) motifs

Tanvir Alam, Meshari Alazmi, Rayan Naser, Franceline Huser, Afaque A. Momin, Veronica Astro, Seungbeom Hong, Katarzyna W. Walkiewicz, Christian G. Canlas, Raphaël Huser, Amal J. Ali, Jasmeen S. Merzaban, Antonio Adamo, Mariusz Jaremko, Łukasz Jaremko, , Stefan T. Arold

The paper identifies LD motifs in the human proteome, reveals their role in cell adhesion and migration, and traces their evolutionary origin to a common ancestor.

Bioinformatics · Sep 28, 2019Peer-reviewedBioinformatics