Łukasz Jaremko

An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer disease

This paper introduces an age-preserving neuronal iSpheroid platform that models human aging and Alzheimer's disease, revealing disease-associated metabolic changes and potential therapeutic targets.

Functional selection in SH3-mediated activation of the PI3 kinase

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

Molecular Basis and Cellular Effects of Janus-Class-Driven Cytoplasmic PYK2 Coacervates

This study identifies a novel mechanism of phase separation driven by the Janus-class KFL region of PYK2, showing its role in kinase activation and cell adhesion.

Probiotic and postbiotic treatment in situ during a marine heat wave improves coral health and promotes specific metabolic and microbiome changes

The paper tests probiotic and postbiotic treatments on corals during a marine heatwave, showing improved photosynthetic efficiency and microbiome/metabolic changes.

A wheat tandem kinase sensor activates an NLR helper to trigger immunity

The paper identifies a two-component resistance mechanism in wheat where a tandem kinase sensor recruits an NLR helper to trigger immunity against fungal pathogens.

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

Functional pangenome analysis suggests inhibition of the protein E as a readily available therapy for COVID-2019.

The paper identifies the envelope protein E as a therapeutic target for COVID-19 and suggests existing drugs that inhibit this protein could prevent ARDS.

Proteome-level assessment of origin, prevalence and function of Leucine-Aspartic Acid (LD) motifs

The paper identifies LD motifs in the human proteome, reveals their role in cell adhesion and migration, and traces their evolutionary origin to a common ancestor.