Stefan T. Arold

This study investigates the role of NATA1 and NATA2 in regulating polyamine acetylation in Arabidopsis, showing that NATA2 is heat-inducible and beneficial under heat stress, while its double knockout is lethal.

The paper identifies a conserved glycoside hydrolase family in leaf rust fungi that interacts with barley LecRKs to mediate non-host resistance, showing functional conservation across cereal species.

This paper demonstrates the use of hierarchically etched MIL-101 nanoreactors to encapsulate and deliver a multi-enzyme pathway for in vitro drug biosynthesis and intracellular function.

The paper uses cryo-electron tomography to visualize the structural architecture of focal adhesions in human fibroblasts, revealing spatial organization and interactions of proteins and cytoskeletal elements.

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

This study identifies a novel mechanism of phase separation driven by the Janus-class KFL region of PYK2, showing its role in kinase activation and cell adhesion.

This study identifies an E3-HTL-substrate complex that reveals how strigolactone perception by the receptor HTL7 is linked to substrate recognition by the E3 ubiquitin ligase MAX2.

This study identifies zaxinone as a ligand for DWARF14 and KARRIKIN INSENSITIVE2 in Arabidopsis, revealing its role in phytohormone regulation and signaling.

The paper introduces a benchmark and algorithm for designing proteins with conformational specificity, demonstrating success in redesigning MAP kinase ERK2 to maintain activity without phosphorylation.

The paper analyzes the structural and functional differences of Arabidopsis CDC48A compared to animal and fungal CDC48 systems, revealing unique cofactor interactions and evolutionary adaptations in plants.

The paper identifies a two-component resistance mechanism in wheat where a tandem kinase sensor recruits an NLR helper to trigger immunity against fungal pathogens.

This study shows lactate enhances NMDA receptor currents through redox-sensitive cysteines in GluN2B and CaMKII interactions, linking astrocyte metabolism to synaptic plasticity.

This paper introduces P-NADs, a ubiquitin-independent protein degradation method using PUX-adaptor proteins and nanobodies, demonstrating their efficacy in human cells and potential for therapeutic applications.

AlphaCRV identifies accurate protein-protein interactions by clustering and ranking conserved binding topologies from AlphaFold predictions.

DeepGO-SE improves protein function prediction for distantly related proteins by using a pretrained large language model and a neuro-symbolic model that leverages GO axioms.

The paper sequences the genome of Plasmodium simium to study its evolutionary history and identify genetic adaptations enabling host-switching to humans.

The paper characterizes the clinical and molecular features of 36 individuals with SETD1B variants, identifying a core phenotype of developmental delay and variable epilepsy, with male predominance and potential sex-linked effects.

The paper defines a genetic barcoding scheme using 10-nucleotide classifiers to classify SARS-CoV-2 clades from genomic data, achieving high accuracy in identifying circulating viral populations.

The paper identifies the envelope protein E as a therapeutic target for COVID-19 and suggests existing drugs that inhibit this protein could prevent ARDS.

The paper introduces iDTPnd, a computational method to identify novel drug targets by analyzing structural signatures of drug binding sites, validated with in vitro experiments on kinase inhibitors.

The paper identifies LD motifs in the human proteome, reveals their role in cell adhesion and migration, and traces their evolutionary origin to a common ancestor.