This study develops pan-specific monoclonal antibodies to detect pseudaminic acids in bacteria, enabling deeper glycoproteomic analysis and improved phagocytosis of multidrug-resistant strains.

bioRxiv · Jul 13, 2025 · PreprintBiochemistry

Transposon-directed insertion-site sequencing (TraDIS) analysis of Enterococcus faecium using nanopore sequencing and a WebAssembly analysis platform

Alexandra L. Krause, Wytamma Wirth, Adrianna M. Turner, Louise M. Judd, Lucy Qian Li, Willem van Schaik, Benjamin P. Howden, Glen P. Carter, Torsten Seemann, Ryan R. Wick, Timothy Paul Stinear, Andrew H. Buultjens, Ian R. Monk

The paper develops a TraDIS platform for Enterococcus faecium using nanopore sequencing and a WebAssembly tool to study vancomycin resistance and persistence.

Microbiology Spectrum · Jun 10, 2025Peer-reviewedMicrobiology

Enteropathogenic Providencia alcalifaciens: A subgroup of P. alcalifaciens that causes diarrhea.

Dieter Bulach, Glen P. Carter, Manuel John Albert

The paper identifies a subgroup of P. alcalifaciens, called enteropathogenic P. alcalifaciens (EPA), that causes diarrhea due to a plasmid-borne type three secretion system (T3SS) locus.

Microorganisms · Jul 19, 2024Peer-reviewedMicrobiology

Complete microbial genomes for public health in Australia and Southwest Pacific

Sarah Louise Baines, Anders Gonçalves da Silva, Glen P. Carter, Amy V. Jennison, Irani U. Rathnayake, Rikki Graham, Vitali Sintchenko, Qinning Wang, Rebecca J. Rockett, Verlaine Joy Timms, Elena Martínez, Susan A. Ballard, Takehiro Tomita, Nicole S. Isles, Kristy Horan, , Communicable Diseases Genomics Network (CDGN)

The paper presents complete microbial genomes for public health in Australia and the Southwest Pacific to enhance global genomic resources and support regional surveillance.

Microbial Genomics · Nov 12, 2020Peer-reviewedGenomics

The changing landscape of VREfm in Victoria, Australia: a state-wide genomic snapshot

Robyn S. Lee, Anders Gonçalves da Silva, Sarah Louise Baines, Janet Strachan, Susan A. Ballard, Glen P. Carter, Jason C. Kwong, Mark B. Schultz, Dieter Bulach, Torsten Seemann, Timothy Paul Stinear, Benjamin P. Howden

The paper analyzes the genomic epidemiology of VREfm in Victoria, Australia, finding that vanA-VREfm is associated with multiple STs and clonal transmission within hospitals, while vanB-VREfm is widespread and disseminated across institutions.

bioRxiv · Mar 28, 2018 · PreprintGenomics

Real-time genomic and epidemiological investigation of a multi-institution outbreak of KPC-producing Enterobacteriaceae: a translational study

Jason C. Kwong, Courtney R. Lane, Finn Romanes, Anders Gonçalves da Silva, Marion Easton, Katie Cronin, Mary Jo Waters, Takehiro Tomita, Kerrie Stevens, Mark B. Schultz, Sarah Louise Baines, Norelle L. Sherry, Glen P. Carter, Andre Mu, Michelle L. Sait, , Benjamin P. Howden

This study combines real-time genomic and epidemiological analysis to identify and manage KPC-producing Enterobacteriaceae outbreaks, revealing transmission networks and informing infection control.

PeerJ · Jan 3, 2018Peer-reviewedGenomics

Genome reconstruction and characterisation of extensively drug-resistant bacterial pathogens through direct metagenomic sequencing of human faeces

Andre Mu, Jason C. Kwong, Nicole S. Isles, Anders Gonçalves da Silva, Mark B. Schultz, Susan A. Ballard, Glen P. Carter, Deborah Anne Williamson, Torsten Seemann, Timothy Paul Stinear, Benjamin P. Howden

This study reconstructs genomes of drug-resistant bacteria from human faeces using metagenomic sequencing and self-organising maps, demonstrating the potential for culture-independent pathogen analysis.

bioRxiv · Jun 22, 2017 · PreprintGenomics

A target-specific assay for rapid and quantitative detection of Mycobacterium chimaera DNA in environmental and clinical specimens

Enrique Zozaya-Valdés, Jessica L. Porter, John Coventry, Janet A. M. Fyfe, Glen P. Carter, Anders Gonçalves da Silva, Torsten Seemann, Paul D. R. Johnson, Andrew James Stewardson, Ivan Bastian, Sally A. Roberts, Benjamin P. Howden, Deborah A. Williamson, Timothy P. Stinear

The paper develops a TaqMan qPCR assay for specific and rapid detection of M. chimaera DNA in clinical and environmental samples, showing higher sensitivity than culture methods.

bioRxiv · Feb 9, 2017 · PreprintMicrobiology