Ian R. Monk

This paper shows that phosphorylation by PknB at T101 promotes WalR dimer formation and strengthens DNA binding, revealing a direct functional link between PknB and WalR.

The paper identifies mutations in the mfd gene in S. aureus isolates from a CRS patient, linking them to a mucoid hyper-biofilm phenotype and increased enterotoxin production.

This study shows that fumarate, regulated by host and pathogen, limits S. aureus growth by blocking metabolic pathways, while FumC enables adaptation through fumarate degradation and utilization.

The paper develops a TraDIS platform for Enterococcus faecium using nanopore sequencing and a WebAssembly tool to study vancomycin resistance and persistence.

This study evaluates variant calling from bacterial genome assemblies versus read-based methods, finding that assembly-based approaches require error-free assemblies to achieve high accuracy.

This study evaluates in vitro resistance development in MRSA to vancomycin, daptomycin, and linezolid, identifying mutations and mechanisms associated with resistance.

RM-seq detects and quantifies antibiotic resistance mutations in bacterial populations with high sensitivity and accuracy.

The paper refutes claims about the essentiality of specific amino acid residues in the WalK sensor kinase of Staphylococcus aureus by showing that observed phenotypes may arise from secondary mutations rather than the intended single amino acid substitutions.