Targeted degradation of α-synuclein prevents PFF-induced aggregation
Bill Carton, Géraldine Gelders, Gajanan J. Sathe, Nur Mehpare Kocatürk, Sascha Röth, Thomas Macartney, Joke Van Elsen, Louis De Muynck, Arjan Buist, Diederik Moechars, Gopal P. Sapkota
This study demonstrates targeted degradation of α-synuclein using a nanobody-guided system, preventing PFF-induced aggregation in neurons.
bioRxiv · Apr 15, 2025 · PreprintNeuroscience