Wolfgang Esser‐Skala

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

Differences between in vivo and ex vivo models drive divergent perturbation outcomes

The paper compares perturbation outcomes in in vivo and ex vivo hematopoietic stem cell models, finding systematic biases and challenges in predicting in vivo effects from ex vivo data.

Reliable interpretability of biology-inspired deep neural networks

This study evaluates interpretability in biology-inspired deep learning models, identifying biases and proposing methods to improve robustness in P-NET trained on patient mutation data.