Author

Jon Zazpe

Centro de Investigación Médica Aplicada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Ainhoa Goñi‐SalaverriiD· 2 shared Brian J.P. HuntlyiD· 2 shared David Lara‐AstiasoiD· 2 shared Diego AlignaniiD· 2 shared Francesco P. MarcheseiD· 2 shared Jake P. Taylor‐KingiD· 2 shared Julen Mendieta-EstebaniD· 2 shared Nikolaus FortelnyiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Ainhoa Goñi‐SalaverriORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens

Laura Pilar Aguado‐Alvaro, Nerea Garitano, Wolfgang Esser‐Skala, Judith R. Sayers, Cynthia del Valle, Daniel Alameda, Julen Mendieta-Esteban, María Eréndira Calleja-Cervantes, Ainhoa Goñi‐Salaverri, Jon Zazpe, Anna Rosaria de Vito, Francesco P. Marchese, Diego Alignani, Juliana Cudini, Torsten Groß, , David Lara‐Astiaso

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

Nature Communications · Nov 26, 2025Peer-reviewedCell Biology

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

David Lara‐Astiaso, Ainhoa Goñi‐Salaverri, Julen Mendieta-Esteban, Nisha Narayan, C Del Valle, T Gross, George Giotopoulos, Mar Navarro-Alonso, Jon Zazpe, Francesco P. Marchese, Natalia Torrea, Isabel A. Calvo, Cécile K. Lopez, Diego Alignani, A Lopez, , Brian J.P. Huntly

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.

bioRxiv · Aug 11, 2022 · PreprintGenomics