PROTAC molecule-mediated SpCas9 protein degradation for precise genome editing
Shengnan Sun, Renhong Sun, Minkang Tan, Maarten Kip, Xiaobao Yang, Baoxu Pang
This paper develops a PROTAC molecule that degrades SpCas9 proteins, enhancing CRISPR genome editing precision by reducing off-target effects.
bioRxiv · Jan 7, 2025 · PreprintBiochemistry