Delay of human early development via in vitro diapause
Dhanur P. Iyer, Vera Anna van der Weijden, Heidar Heidari Khoei, Afshan McCarthy, Teresa Rayón, Claire S. Simon, Ilona Dunkel, Sissy E. Wamaitha, Kay T. Elder, Phil Snell, Leila Christie, Edda G. Schulz, Kathy K. Niakan, Nicolas C. Rivron, Aydan Bulut-Karslıoğlu
This study shows that human blastoids and pluripotent stem cells can enter a dormant state via mTOR inhibition, with distinct temporal dynamics compared to mice.
bioRxiv · May 29, 2023 · PreprintDevelopmental Biology