Kay T. Elder

This study shows that restoring Shugoshin 1 reduces chromosome errors in aged human eggs by preserving cohesion.

This paper develops an in vitro model of the human chorion using blastocysts to generate trophoblast organoids and extraembryonic mesoderm cells, enabling study of placental development and pathophysiology.

The paper shows that inhibiting ERK signaling expands epiblast cells capable of becoming naive pluripotent stem cells in humans, while FGF stimulation expands hypoblast markers.

This study uses live imaging to show mitotic errors and lineage plasticity in human embryos before implantation, revealing implications for aneuploidy mosaicism.

The paper identifies transcription factors that can convert human embryonic stem cells into trophoblast stem cells, revealing their role in early placental development.

The paper evaluates gene regulatory network prediction methods in early human embryos, finding that MICA, combining mutual information with chromatin accessibility, provides more reproducible and biologically meaningful results.

This study shows that human blastoids and pluripotent stem cells can enter a dormant state via mTOR inhibition, with distinct temporal dynamics compared to mice.

The paper investigates the conservation of Hippo signaling in the first lineage specification event across four mammalian species, finding that inhibiting the Hippo pathway drives ectopic trophectoderm initiation in all species.

The paper shows KLF17 can induce a naive-like transcriptome in primed hESCs but is not required for naive pluripotency establishment in vitro.

The paper identifies an error-prone mechanism of parental genome unification in bovine embryos that leads to aneuploidy, with defects in nucleolar clustering correlating with embryo development failure.