SRC-mediated and TKS5-enabled podosome formation is an inherent property of IPF fibroblasts, promoting ECM invasion and pulmonary fibrosis
Ilianna Barbayianni, Paraskevi Kanellopoulou, Dionysiοs Fanidis, Eleftheria-Dimitra Ntouskou, Dimitris Nastos, Apostolos Galaris, Vaggelis Harokopos, Pantelis Hatzis, Eliza Tsitoura, Robert Homer, Naftali Kaminski, Katerina M. Antoniou, Bruno Crestani, Argyrios Tzouvelekis, Vassilis Aidinis
This study identifies TKS5-mediated podosome formation in IPF fibroblasts as a driver of ECM invasion and pulmonary fibrosis, with potential therapeutic targeting via src kinase inhibition.
bioRxiv · Jan 25, 2023 · PreprintMolecular Biology