Vassilis Aidinis

This paper introduces EL244, a dual ATX inhibitor and PPARγ agonist for treating pulmonary fibrosis, showing reduced LPA levels and fibrosis in a bleomycin model.

This study shows that ERAP1 inhibition alters the immunopeptidome and proteome in cancer cells, affecting metabolism and stress responses, but only a small fraction of proteomic changes impact the immunopeptidome.

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

This study identifies TKS5-mediated podosome formation in IPF fibroblasts as a driver of ECM invasion and pulmonary fibrosis, with potential therapeutic targeting via src kinase inhibition.

The paper shows that ATX expression from GFAP+ cells is essential for embryonic development and is reactivated in EAE, linking it to chronic inflammation.