Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis
Alexandra E. Cuaycal, Elizabeth Ashley Butterworth, Scott E. Stimpson, Jing Chen, Nataliya I. Lenchik, Leigh A Baratta, Edward A. Phelps, Scott S. Grieshaber, Mark A. Atkinson, Weijun Qian, Martha Campbell‐Thompson, Ivan Gerling, Clayton E. Mathews
This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.
bioRxiv · Aug 3, 2026 · PreprintPhysiology