Elizabeth Ashley Butterworth

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

Laser-microdissected islets of 3 multiple-autoantibody-positive stage 1 type 1 diabetes donors versus matched controls show 202 altered proteins: immune and glycolytic up, translation and ER-stress proteins down.