Author

Alexandra E. Cuaycal

University of FloridaORCID 0000-0002-9060-6326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Edward A. PhelpsiD· 4 shared Dylan SmurlickiD· 3 shared Mark A. AtkinsoniD· 3 shared Clayton E. MathewsiD· 2 shared Elizabeth Ashley ButterworthiD· 2 shared Ivan GerlingiD· 2 shared Jing CheniD· 2 shared Martha Campbell‐ThompsoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Edward A. PhelpsORCID

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4 papers

Recent·Most cited

Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets

Austin E. Stis, Charles S Lazimi, Sandra M. Ferreira, Alexandra E. Cuaycal, Dylan Smurlick, D. Walker Hagan, Taylor Nakayama, Sunil Gandhi, Emery Smith, Timothy Spicer, Edward A. Phelps

The paper reveals that GABA secretion from pancreatic beta cells occurs via the LRRC8A/D VRAC channel and is coordinated with calcium influx and depolarization, not vesicular release or insulin secretion.

Molecular Metabolism · Sep 25, 2026Peer-reviewedPhysiology

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

Alexandra E. Cuaycal, Elizabeth Ashley Butterworth, Scott E. Stimpson, Jing Chen, Nataliya I. Lenchik, Leigh A Baratta, Edward A. Phelps, Scott S. Grieshaber, Mark A. Atkinson, Weijun Qian, Martha Campbell‐Thompson, Ivan Gerling, Clayton E. Mathews

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

bioRxiv · Aug 3, 2026 · PreprintPhysiology

Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices

Matthew W. Becker, Matthew E. Brown, Katherine Wiseman, Ana Laura Chiodetti, Mollie K. Huber, Alexandra E. Cuaycal, Pumin Sintara, Sandra Mara Ferreira, Dylan Smurlick, Jessie M. Barra, Andrew M. Ladd, Denise Minerva Drotar, Mark A. Atkinson, Peter Weber, Hussein Al‐Mossawi, , Edward A. Phelps

This study shows that ImmTAAI, a beta cell-targeted PD-1 agonist, inhibits T cell activity in human type 1 diabetes by increasing T cell motility and reducing cytokine secretion.

bioRxiv · Oct 21, 2025 · PreprintBioengineering

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Mollie K. Huber, Adrienne E. Widener, Alexandra E. Cuaycal, Dylan Smurlick, Elizabeth Ashley Butterworth, Nataliya I. Lenchik, Jing Chen, Maria L. Beery, Helmut Hiller, Ellen Verney, Irina Kusmartseva, Marjan Slak Rupnik, Martha Campbell‐Thompson, Ivan Gerling, Mark A. Atkinson, , Edward A. Phelps

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

Cell Reports · Aug 27, 2025Peer-reviewedPhysiology