Author

Nataliya I. Lenchik

University of Tennessee Health Science CenterORCID 0000-0002-6308-1747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra E. CuaycaliD· 2 shared Clayton E. MathewsiD· 2 shared Edward A. PhelpsiD· 2 shared Elizabeth Ashley ButterworthiD· 2 shared Ivan GerlingiD· 2 shared Jing CheniD· 2 shared Mark A. AtkinsoniD· 2 shared Martha Campbell‐ThompsoniD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Alexandra E. CuaycalORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintAug 3, 2026

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesis

Alexandra E. Cuaycal, Elizabeth Ashley Butterworth, Scott E. Stimpson…·Clayton E. Mathews

This study identifies transcriptional impairments in mitochondrial and protein homeostasis pathways in islets during type 1 diabetes pathogenesis, independent of T-cell infiltration.

DOI 10.64898/2026.07.29.741469

humanbulk RNA-seq

𝕏 PostBluesky

PhysiologyCell ReportsPeer-reviewedAug 27, 2025

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Mollie K. Huber, Adrienne E. Widener, Alexandra E. Cuaycal…·Edward A. Phelps

This study shows that beta cell dysfunction occurs in type 1 diabetes independently of T cell infiltration, using human pancreas tissue slices from recently diagnosed patients.

35 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky