Oral oxycodone self-administration leads to features of opioid addiction in male and female mice
Richard A. Slivicki, Tom Earnest, Yu‐Hsuan A. Chang, Rajesh Pareta, Eric Casey, Junnan Li, Jessica R. Tooley, Kavitha Abiraman, Yvan M. Vachez, Drew K. Wolfe, Jason T. Sackey, Robert W. Gereau, Bryan A. Copits, Alexxai V. Kravitz, Meaghan C. Creed
This study shows that oral oxycodone self-administration in mice leads to features of opioid addiction, including escalation, dependence, and relapse behavior.
bioRxiv · Jul 19, 2022 · PreprintNeuroscience