Richard A. Slivicki

PixelPaws: a low-cost, open-source integrated platform for automated scoring of mouse behaviors

PixelPaws is an open-source platform for automated mouse behavior scoring that validates its performance against human observers in pain and opioid withdrawal assays.

Impact of Δ9-tetrahydrocannabinol and oxycodone co-administration on measures of antinociception, dependence, circadian activity, and reward in mice

This study examines how combining Δ9-THC and oxycodone affects pain relief, dependence, circadian activity, and reward in mice, finding enhanced antinociception without increased dependence but with increased reward.

A multi-omic atlas of human autonomic and sensory ganglia implicates cell types in peripheral neuropathies

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

A Reference Atlas of the Human Dorsal Root Ganglion

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

Single nucleus multi-omic atlas of human dorsal root ganglia reveals the contribution of nonneuronal cell types to pain

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

Multimodal profiling of human sensory neurons links electrical properties to transcriptional identity

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

Expression of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Human Peripheral Nervous System: Implications for the Putative Pathogenic Role of FGFR3 Autoantibodies in Neuropathy

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

An Autonomous Implantable Device for the Prevention of Death from Opioid Overdose

The paper introduces an implantable device that autonomously detects and treats opioid overdose, improving survival rates by delivering naloxone and alerting first responders.

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons

This study characterizes bradykinin receptor expression and function in human dorsal root ganglia neurons, finding conserved acute hyperexcitability and age/pain history-related B1 receptor expression.

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

Oral oxycodone self-administration leads to features of opioid addiction in male and female mice

This study shows that oral oxycodone self-administration in mice leads to features of opioid addiction, including escalation, dependence, and relapse behavior.

The cannabinoid agonist CB-13 produces peripherally mediated analgesia in mice but elicits tolerance and signs of CNS activity with repeated dosing

This study evaluates CB-13, a peripherally selective CB1 agonist, showing it reduces pain in mice but develops tolerance and CNS effects with repeated dosing.

Modeling features of addiction with an oral oxycodone self-administration paradigm

This paper introduces an oral oxycodone self-administration paradigm in mice to model prescription opioid use and its transition to abuse.