Author

Jordan P. Lewandowski

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Genomics· 3 Genetics· 1

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Research Focus:variant effect prediction· 2

Frequent Co-Authors

John L. RinniD· 4 shared Chiara GerhardingeriD· 2 shared Christian MuchiD· 2 shared Abigail F. GroffiD· 1 shared Alexander MeissneriD· 1 shared Audrey R. WatsoniD· 1 shared Christine M. DistècheiD· 1 shared Christopher KirbyiD· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersGenomics

John L. RinnORCID

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4 papers

Recent·Most cited

The temporal dynamics of lncRNA Firre-mediated epigenetic and transcriptional regulation

Christian Much, Erika L. Lasda, Isabela Tiemy Pereira, Tenaya K. Vallery, Daniel Ramirez, Jordan P. Lewandowski, Robin D. Dowell, Michael J. Smallegan, John L. Rinn

This study investigates the temporal dynamics of lncRNA Firre-mediated epigenetic and transcriptional regulation, showing rapid and persistent effects on gene expression.

bioRxiv · May 15, 2022 · PreprintGenomics

Trans- and cis-acting effects of the lncRNA Firre on epigenetic and structural features of the inactive X chromosome

He Fang, Giancarlo Bonora, Jordan P. Lewandowski, Jitendra Thakur, Galina N. Filippova, Steven Henikoff, Jay Shendure, Zhijun Duan, John L. Rinn, Xinxian Deng, William Stafford Noble, Christine M. Distèche

This study shows that Firre RNA has trans-acting effects on the inactive X chromosome, affecting histone modifications, PRC2 complex components, and chromatin structure.

Nature Communications · Nov 27, 2020Peer-reviewedGenomics

In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

Daniel Andergassen, Zachary D. Smith, Jordan P. Lewandowski, Chiara Gerhardinger, Alexander Meissner, John L. Rinn

This study shows that Firre and Dxz4 deletions in mice affect autosomal gene regulation without impacting XCI.

eLife · Nov 18, 2019Peer-reviewedGenetics

The Tug1 Locus is Essential for Male Fertility

Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang, Emily Jacobs-Palmer, Nydia P. Chang, Christian Much, Kyle M. Turner, Christopher Kirby, Jana Felicitas Schulz, Clara-Louisa Müller, Nimrod Daniel Rubinstein, Abigail F. Groff, Steve C. Liapis, Chiara Gerhardinger, , John L. Rinn

The paper identifies Tug1 as essential for male fertility, showing it has three distinct regulatory activities: a cis DNA repressor, a trans-acting lncRNA, and a conserved peptide affecting mitochondrial function.

bioRxiv · Feb 28, 2019 · PreprintGenomics