Rahul Kaushik

Intrinsic Cellular Persistent Firing Sustains Hippocampal Spatial Representations during Working Memory

The paper shows that hippocampal place cells maintain spatial information through intrinsic persistent firing via TRPC4 channels during working memory tasks in mice.

Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation

This study shows that reducing neurocan in the prefrontal cortex impairs cognitive flexibility and perisomatic GABAergic innervation in mice.

Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons

This study investigates the role of Neurocan in regulating axon initial segment organization and neuronal activity in cultured cortical neurons through knockdown and knockout approaches.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.

Heparan sulfates regulate axonal excitability and context generalization through Ca2+/calmodulin-dependent protein kinase II

This study shows that heparan sulfates regulate axonal excitability and context generalization via CaMKII, with heparinase treatment affecting neuronal function and memory.

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

The paper identifies a novel ECM remodeling mechanism through endocytosis and resurfacing of Tenascin-R near synapses, occurring within 3 days and dependent on activity.

LGI1 downregulation increases neuronal circuit excitability

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.

Epigenetic mechanism of carbohydrate sulfotransferase 3 (CHST3) downregulation in the aging brain

This study identifies age-related downregulation of CHST3 gene expression in the aging mouse brain, linked to epigenetic changes and cognitive decline.

Dopamine modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses

This study shows dopamine modulates ECM integrity at excitatory synapses via D1 receptors and proteases ADAMTS-4/5, affecting brevican and aggrecan cleavage.