Aleksandra Pawlak

This study compares the biology and genetic drivers of human and canine invasive urothelial carcinoma, finding shared cellular organization but distinct mutations and platform effects in organoids.

This paper develops a time-based drug screening platform to assess clinical utility by integrating pharmacokinetic-pharmacodynamic models and analyzing drug potency and kinetics in cancer cell lines.

This paper establishes a canine urothelial carcinoma organoid repository for comparative and translational carcinoma studies, showing genomic and transcriptomic fidelity to tissue and potential for drug testing.

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.