Christopher Zdyrski

This study compares the biology and genetic drivers of human and canine invasive urothelial carcinoma, finding shared cellular organization but distinct mutations and platform effects in organoids.

The paper develops chicken lung organoids to model avian influenza virus-host interactions and finds they contain diverse cell types and express relevant viral infection genes.

The paper introduces OrganoidChip+, a microfluidic platform for culturing and high-content imaging of adult stem cell-derived organoids, showing improved growth rates and imaging capabilities compared to traditional methods.

This paper develops a time-based drug screening platform to assess clinical utility by integrating pharmacokinetic-pharmacodynamic models and analyzing drug potency and kinetics in cancer cell lines.

This paper establishes a canine urothelial carcinoma organoid repository for comparative and translational carcinoma studies, showing genomic and transcriptomic fidelity to tissue and potential for drug testing.

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.

The paper develops the first turtle-derived hepatic organoids from multiple species, enabling in vitro studies of unique adaptations and biomedical applications.

This study cultivates and characterizes new canine organoid lines from endometrium and pancreas, comparing them with existing lines using bulk RNA-seq to identify cell types and differences between two genetically related canines.