Karin Allenspach

Epithelial to mesenchymal transition and M2 macrophages drive aggressiveness in murine and human sarcomatoid urothelial carcinoma.

The paper develops a murine model of sarcomatoid urothelial carcinoma (SUC) and finds it shares molecular and immunological features with human SUC, suggesting its use for therapeutic research.

Inverse-scattering in biological samples via beam-propagation

This paper demonstrates that using an amplitude-only cost function with angular and defocus diversity in multi-slice beam propagation improves inverse-scattering reconstruction quality in biological samples.

Convergent biology, divergent drivers: a cross-species comparison of human and canine invasive urothelial carcinoma

This study compares the biology and genetic drivers of human and canine invasive urothelial carcinoma, finding shared cellular organization but distinct mutations and platform effects in organoids.

Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction

The paper develops chicken lung organoids to model avian influenza virus-host interactions and finds they contain diverse cell types and express relevant viral infection genes.

OrganoidChip+: a Microfluidic Platform for Culturing, Staining, Immobilization, and High-Content Imaging of Adult Stem Cell-Derived Organoids

The paper introduces OrganoidChip+, a microfluidic platform for culturing and high-content imaging of adult stem cell-derived organoids, showing improved growth rates and imaging capabilities compared to traditional methods.

Development of a Time-based Drug Screening Platform for Improved Clinical Translation

This paper develops a time-based drug screening platform to assess clinical utility by integrating pharmacokinetic-pharmacodynamic models and analyzing drug potency and kinetics in cancer cell lines.

Establishing a Canine Urothelial Organoid Repository: A Platform for Comparative and Translational Carcinoma Studies

This paper establishes a canine urothelial carcinoma organoid repository for comparative and translational carcinoma studies, showing genomic and transcriptomic fidelity to tissue and potential for drug testing.

Targeted next-generation sequencing of Candidate Regions Identified by GWAS Revealed SNPs Associated with IBD in GSDs

The paper uses targeted NGS to identify functional SNPs and pathways associated with IBD in GSDs, revealing genetic markers for treatment response.

Frequency and Characterization of Rare Histologic Subtypes in Canine Invasive Urothelial Carcinoma

This study identifies higher frequencies of specific histologic subtypes and divergent differentiation in canine urothelial carcinoma compared to previous reports, suggesting dogs as a model for human sarcomatoid UC.

Characterization of the First Turtle Organoids: A Model for Investigating Unique Adaptations with Biomedical Potential

The paper develops the first turtle-derived hepatic organoids from multiple species, enabling in vitro studies of unique adaptations and biomedical applications.

A Multi-Tissue Comparison and Molecular Characterization of Canine Organoids

This study cultivates and characterizes new canine organoid lines from endometrium and pancreas, comparing them with existing lines using bulk RNA-seq to identify cell types and differences between two genetically related canines.