Kenn Gerdes

This study identifies phage portal proteins as factors that counteract bacterial stringent response by inhibiting alarmone synthetases, revealing a conserved viral strategy to overcome host stress physiology.

The paper shows that basal ppGpp levels in E. coli are actively regulated by SpoT and are essential for metabolic homeostasis and acid resistance.

This study identifies novel defense systems and functional diversity within the RelE/ParE superfamily using bioinformatics analysis of BECR-fold toxins.

This paper analyzes the genetic contexts of HicA toxin domains in prokaryotes, revealing their diversity and potential roles in anti-phage defense through bioinformatics and structural modeling.