This study identifies HAdV-D-specific mechanisms of HMGB1 secretion and subepithelial infiltrate formation in EKC by infected corneal epithelial cells.

PLoS Pathogens · May 14, 2025Peer-reviewedMicrobiology

OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus

Ashrafali Mohamed Ismail, Amrita Saha, Kimberly A. Morrissey, Dominic K. LUNDQUIST, Emanuel Garcia, Praveen Kumar Balne, Judy L. Cannon, James Chodosh, Jaya Rajaiya

This study identifies OCT4's role in repressing adenovirus E3 gene expression through binding to the ITR, affecting immune evasion and viral replication.

bioRxiv · Apr 23, 2025 · PreprintCell Biology

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

Jie Liu, Fengyang Lei, Chiara Romano, Bin Yan, Tain Cao, Naiwen Cui, Jyoti Sharma, Victor Correa, Lara Roach, Savvas Kikolaou, Kristen M. Pitts, James Chodosh, Daniel Enrique Maidana, Demetrios G. Vavvas, Milica A. Margeta, , Eleftherios I. Paschalis

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

bioRxiv · Sep 9, 2024 · PreprintImmunology

CSF1R inhibition by a small molecule inhibitor affects hematopoiesis and the function of macrophages.

Fengyang Lei, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G. Vavvas, Eleftherios I. Paschalis

This study shows that CSF1R inhibition by PLX5622 affects both myeloid and lymphoid compartments, alters macrophage function, and impacts tissue-resident macrophages beyond microglia.

bioRxiv · Dec 27, 2019 · PreprintNeuroscience