Demetrios G. Vavvas

A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

CSF1R inhibition by a small molecule inhibitor affects hematopoiesis and the function of macrophages.

This study shows that CSF1R inhibition by PLX5622 affects both myeloid and lymphoid compartments, alters macrophage function, and impacts tissue-resident macrophages beyond microglia.

RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization

This study shows that RIP1 kinase inhibition reduces pathological angiogenesis by modulating macrophage polarization in mouse models.

Percentage of Foveal versus Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-related Macular Degeneration

The paper investigates the relationship between visual acuity and the percentage of foveal geographic atrophy in age-related macular degeneration, finding that foveal GA percentage is significantly associated with VA impairment.

Blocking the Necroptosis Pathway Decreases RPE and Photoreceptor Damage Induced by NaIO3

This study shows that blocking the necroptosis pathway reduces RPE and photoreceptor damage caused by NaIO3 in both cell and animal models.

Combined inhibition of apoptosis and necrosis promotes transient neuroprotection of retinal ganglion cells and partial axon regeneration after optic nerve damage

This study shows that combining inhibition of apoptosis and necrosis can transiently protect retinal ganglion cells and promote partial axon regeneration after optic nerve damage.