Author

Fengyang Lei

Massachusetts Eye and Ear InfirmaryORCID 0000-0002-9169-8314Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Eleftherios I. PaschalisiD· 3 shared Demetrios G. VavvasiD· 2 shared James ChodoshiD· 2 shared Naiwen CuiiD· 2 shared Bin YaniD· 1 shared Chengxin ZhouiD· 1 shared Chiara Romano· 1 shared Daniel Enrique MaidanaiD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPathology

Eleftherios I. PaschalisORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

Zhengping Hu, Issahy Cano, Fengyang Lei, Jie Liu, Ramon Bossardi Ramos, Harper B. Gordon, Eleftherios I. Paschalis, Magali Saint‐Geniez, Yin‐Shan Ng, Patrìcia A. D'Amore

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Circulation Research · Nov 25, 2024Peer-reviewedPathology

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

Jie Liu, Fengyang Lei, Chiara Romano, Bin Yan, Tain Cao, Naiwen Cui, Jyoti Sharma, Victor Correa, Lara Roach, Savvas Kikolaou, Kristen M. Pitts, James Chodosh, Daniel Enrique Maidana, Demetrios G. Vavvas, Milica A. Margeta, , Eleftherios I. Paschalis

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

bioRxiv · Sep 9, 2024 · PreprintImmunology

CSF1R inhibition by a small molecule inhibitor affects hematopoiesis and the function of macrophages.

Fengyang Lei, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G. Vavvas, Eleftherios I. Paschalis

This study shows that CSF1R inhibition by PLX5622 affects both myeloid and lymphoid compartments, alters macrophage function, and impacts tissue-resident macrophages beyond microglia.

bioRxiv · Dec 27, 2019 · PreprintNeuroscience