Eleftherios I. Paschalis

A TROP2/Claudin Program Mediates Immune Exclusion to Impede Checkpoint Blockade in Breast Cancer

This study identifies TROP2 as a regulator of tight junction-mediated immune exclusion in TNBC, showing that targeting TROP2 enhances anti-PD1 therapy response.

Deletion of the endothelial glycocalyx component endomucin leads to impaired glomerular structure and function

This study shows that deleting endomucin in endothelial cells causes structural and functional issues in kidney glomeruli, including podocyte damage and albuminuria.

Chromatin and transcriptional adaptation accompany monocyte engraftment in the injured retina

The paper examines how engrafted monocytes adapt chromatin and transcriptionally in the injured retina, showing shared and distinct features with host microglia.

CSF1R inhibition by a small molecule inhibitor affects hematopoiesis and the function of macrophages.

This study shows that CSF1R inhibition by PLX5622 affects both myeloid and lymphoid compartments, alters macrophage function, and impacts tissue-resident macrophages beyond microglia.

RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization

This study shows that RIP1 kinase inhibition reduces pathological angiogenesis by modulating macrophage polarization in mouse models.