Elly M. Hol

The paper uses single-cell proteomics to show that GFAP mutations in Alexander disease lead to ETC dysfunction and metabolic adaptation via the G3P shuttle.

This study creates a transcriptomic atlas of the human ventral tegmental area, identifies cell types and their functional connectivity, and links them to psychiatric disorders and BMI.

This study shows that deleting GFAP and Vimentin in astrocytes reduces early synaptic and cognitive dysfunction in Alzheimer's mice by improving protein synthesis and astrocyte function.

This study identifies loss of lamin-B1 and nuclear deformations as markers of astrocyte senescence in vitro and in aged human hippocampus.

This study examines the transcriptomic response of human monocyte-derived microglia-like cells to Aβ1-42 oligomers, finding increased metallothionein expression and no inflammatory or HAM/DAM profiles.

This study reports viscoelastic maps of the hippocampus in APP/PS1 Alzheimer's disease mice, showing increased stiffness and viscous dissipation compared to wild-type mice.

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.

This study maps the viscoelastic properties of mouse brain tissue and links them to structural features and age-related changes.