Cancer BiologybioRxivPreprint
Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia
Charlien Vandersmissen, Sofie Demeyer, Kris Jacobs…·Jan Cools
The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.
DOI 10.1101/2024.03.01.582944