Author

Sofie Demeyer

Universitair Ziekenhuis LeuvenORCID 0000-0002-8193-5734Unclaimed ORCID profile · follow to get notified of new preprints

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Sofie Demeyer1 paper

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexandra Bacquelaine VelosoiD· 2 shared Heidi SegersiD· 2 shared Jan CoolsiD· 2 shared Kris JacobsiD· 2 shared Lien BoogaertsiD· 2 shared Alice Bernard· 1 shared Anouk Bleuart· 1 shared Benoît VanhollebekeiD· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Alexandra Bacquelaine VelosoORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMar 3, 2024

Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis

Alexandra Bacquelaine Veloso, Thomas Slegers, Jente M. Schoenaker…·Marlies Vanden Bempt

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

DOI 10.1101/2024.03.03.583195

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 1, 2024

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

Charlien Vandersmissen, Sofie Demeyer, Kris Jacobs…·Jan Cools

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

DOI 10.1101/2024.03.01.582944

humangenetic perturbation / CRISPR

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Developmental BiologyBMC BiologyPeer-reviewedFeb 27, 2024

The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish

Alexandra Bacquelaine Veloso, Anouk Bleuart, Louise Conrard…·Maud Martin

This study identifies Sorbs1's role in zebrafish lymphatic and venous vessel development, showing it regulates cytoskeleton dynamics and BMP signaling, distinct from Vegfc pathways.

7 citations

zebrafishexperimental assay

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