The Endo-GeneScreen Platform Identifies Drug-Like Probes that Regulate Endogenous Protein Levels within Physiological Contexts
Preston N. Samowitz, László Radnai, Thomas Vaissière, Sheldon D. Michaelson, Camilo J. Rojas, Ryan Mitchell, Murat Kılınç, Austin W. Edwards, Justin Shumate, Richard Hawkins, Virneliz Fernández-Vega, Timothy Spicer, Louis D. Scampavia, Theodore M. Kamenecka, Courtney A. Miller, Gavin Rumbaugh
The paper introduces Endo-GeneScreen, a platform that identifies small molecules regulating endogenous protein levels, and demonstrates its application in finding probes for Syngap1-related neurodevelopmental disorder.
Nature Communications · Dec 9, 2025Peer-reviewedNeuroscience