Thomas Vaissière

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

This study shows that Syngap1 haploinsufficiency in mice causes opposing cortical activity patterns, with reduced sensory responses and increased movement/arousal activity, revealing cell-type-dependent effects on network states.

The paper introduces Endo-GeneScreen, a platform that identifies small molecules regulating endogenous protein levels, and demonstrates its application in finding probes for Syngap1-related neurodevelopmental disorder.

This study shows that Syngap1 in cortical neurons is essential for sensorimotor integration and perception by shaping neural dynamics and connectivity.

This study shows Syngap1 regulates plasticity of silent neurons in the somatosensory cortex during sensory experience, with implications for neurodevelopmental disorders.

This study shows that restoring SynGAP protein in adult Syngap1 heterozygous mice improves memory, seizure susceptibility, and brain activity patterns.