Sheldon D. Michaelson

This study shows that Syngap1 haploinsufficiency in mice causes opposing cortical activity patterns, with reduced sensory responses and increased movement/arousal activity, revealing cell-type-dependent effects on network states.

The paper introduces Endo-GeneScreen, a platform that identifies small molecules regulating endogenous protein levels, and demonstrates its application in finding probes for Syngap1-related neurodevelopmental disorder.

This study shows that Syngap1 in cortical neurons is essential for sensorimotor integration and perception by shaping neural dynamics and connectivity.

This study shows Syngap1 controls membrane excitability in cortical neurons, which is essential for proper circuit assembly during brain development.

This study shows Syngap1 regulates plasticity of silent neurons in the somatosensory cortex during sensory experience, with implications for neurodevelopmental disorders.

This study shows that NPY Y5 receptors mediate dendritic remodeling in BLA neurons, influencing stress resilience through structural and functional changes.