The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.

eLife · Mar 22, 2022Peer-reviewedMolecular Biology

Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women with Alzheimer's Disease

Manish D. Paranjpe, Stella A. Belonwu, Jason K Wang, Tomiko Oskotsky, Aarzu Gupta, Alice L. Taubes, Kelly A. Zalocusky, Ishan Paranjpe, Benjamin Scott Glicksberg, Yadong Huang, Marina Sirota, Alzheimer’s Disease Neuroimaging Initiative

This study identifies sex-specific immune dysregulation in Alzheimer's Disease through meta-analysis of gene expression in brain and blood samples.

Frontiers in Aging Neuroscience · Sep 30, 2021Peer-reviewedNeuroscience

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosus

Gaia Andreoletti, Cristina M. Lanata, Ishan Paranjpe, Tia S. Jain, Joanne Nititham, Kimberly E. Taylor, Alexis J. Combes, Lenka Maliskova, Chun Ye, Patricia Katz, Maria Dall’Era, Jinoos Yazdany, Lindsey A. Criswell, Marina Sirota

This study identifies ethnicity-specific transcriptomic subgroups in SLE patients using RNA-seq data and correlates them with disease activity.

bioRxiv · Oct 30, 2020 · PreprintBioinformatics