Author

Sean Chen

James J. Peters VA Medical CenterORCID 0000-0001-8343-0302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aaron DeLoughery· 1 shared Alexander EthelliD· 1 shared Alexander Neckelmann· 1 shared Alyssa Sancio· 1 shared Andrew J. DworkiD· 1 shared Angus Y. Lee· 1 shared Benjamin J. RauchiD· 1 shared Bohong ZhangiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

Aaron DeLoughery

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintJan 29, 2025

Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease

Benjamin J. Rauch, Aaron DeLoughery, Renan B. Sper…·Lucas B. Harrington

This paper develops NanoCas, a compact CRISPR nuclease, and demonstrates its efficacy in editing non-liver tissues in non-human primates.

8 citations

non-human primateCRISPR screen

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Molecular BiologyeLifePeer-reviewedMar 22, 2022

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Djem U. Kissiov, Alexander Ethell, Sean Chen…·David H. Raulet

The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.

17 citations

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GenomicsbioRxivPreprintFeb 2, 2019

Brain-derived circulating cell-free DNA defines the brain region and cell specific origins associated with neuronal atrophy

Zac Chatterton, Natalia Mendelev, Sean Chen…·Fatemeh G. Haghighi

The paper identifies brain-derived circulating cell-free DNA as a peripheral biomarker specific to cell-type and brain-region origins in neurotrauma and neurodegeneration.

12 citations

humanDNA methylation

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