Author

Angus Y. Lee

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Dmitri Ivanovich KotoviD· 2 shared Harmandeep S Dhaliwal· 2 shared Kristen C. WittiD· 2 shared Ophelia V. LeeiD· 2 shared Roberto A. Chavez· 2 shared Russell E. VanceiD· 2 shared Stefan A. FattingeriD· 2 shared A. C. LariiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Dmitri Ivanovich KotovORCID

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Author profile →

4 papers

Recent·Most cited

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

Stefan A. Fattinger, Parisi Bianca, Roberto A. Chavez, Marian R. Fairgrieve, Ophelia V. Lee, Kristen C. Witt, Jesse J Rodriguez, Elizabeth A Turcotte, Ella C. Brydon, Harmandeep S Dhaliwal, Angus Y. Lee, Dmitri Ivanovich Kotov, Russell E. Vance

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

Cell Host & Microbe · Aug 14, 2026Peer-reviewedImmunology

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia V. Lee, David J. Turner, A. C. Lari, Moritz M. Gaidt, Roberto A. Chavez, Stefan A. Fattinger, Preethy Abraham, Harmandeep S Dhaliwal, Angus Y. Lee, , Russell E. Vance

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

Nature · Jun 11, 2025Peer-reviewedImmunology

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

Yoav Ben‐Simon, Marcus J. Hooper, Sujatha Narayan, Tanya L. Daigle, Deepanjali Dwivedi, Sharon W. Way, Aaron Oster, David A. Stafford, John K. Mich, Michael J. Taormina, Refugio A. Martinez, Ximena Opitz-Araya, Jada R. Roth, Jason R. Alexander, Shona W. Allen, , Shea T. Ransford

The paper develops a toolkit of transgenic mouse lines and enhancer AAVs for selective targeting of cortical cell populations using transcriptomic and epigenomic data.

Cell · May 1, 2025Peer-reviewedNeuroscience

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Djem U. Kissiov, Alexander Ethell, Sean Chen, Natalie K. Wolf, Chen‐Yu Zhang, Susanna M. Dang, Yeara Jo, Katrine N. Madsen, Ishan Paranjpe, Angus Y. Lee, Bryan Chim, Stefan Adi Muljo, David H. Raulet

The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.

eLife · Mar 22, 2022Peer-reviewedMolecular Biology