Author

Zdeněk Spáčil

Masaryk UniversityORCID 0000-0002-7505-4332Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Durga JhaiD· 3 shared Dáša BohačiakováiD· 2 shared Jiřı́ DamborskýiD· 2 shared Tereza VáňováiD· 2 shared Aleš HampliD· 1 shared Anthony LegrandiD· 1 shared Antonín KunkaiD· 1 shared Bára Černá· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Durga JhaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 30, 2023

Apolipoprotein-based regulation of ganglioside metabolism upon secretase activity inhibition in iPSC-derived cerebral organoids

Durga Jha, Tereza Váňová, Dáša Bohačiaková, Zdeněk Spáčil

This study investigates how secretase inhibitors affect ganglioside metabolism in iPSC-derived cerebral organoids with ApoE3 and ApoE4 variants, showing increased ganglioside and ceramide levels in ApoE4 organoids.

DOI 10.1101/2023.08.30.555505

humanbulk RNA-seq

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NeurosciencebioRxivPreprintAug 30, 2023

Brain map of aging-induced alterations in membrane ganglioside pattern

Durga Jha, Gabriela Dovrtělová, Petr Telenský…·Zdeněk Spáčil

The paper analyzes ganglioside profiles in rat brains and fluids across age and regions, finding age-related shifts in a-series to b-series ratios and region-specific changes.

DOI 10.1101/2023.08.30.555520

ratmetabolomics

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NeurosciencebioRxivPreprintOct 9, 2022

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

Michal Nemergut, Sérgio M. Marques, Lukáš Uhrík…·Martin Marek

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.

1 citation

humanproteomics

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