Author

Lukáš Uhrík

Masaryk Memorial Cancer InstituteORCID 0000-0002-6077-4249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Lenka HernychováiD· 2 shared Anthony LegrandiD· 1 shared Antonín KunkaiD· 1 shared Bořivoj VojtěšekiD· 1 shared Darshak Chandulal GadaraiD· 1 shared Dáša BohačiakováiD· 1 shared David BednářiD· 1 shared Durga JhaiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Lenka HernychováORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Multi-omics integration in Esophageal Adenocarcinoma reveals therapeutic targets and EAC-specific regulation of protein abundances

J. Robert O’Neill, Marcos Yébenes Mayordomo, Goran Mitulović, Sofian Al Shboul, Georges Bedran, Jakub Faktor, Lenka Hernychová, Lukáš Uhrík, Maria Gómez-Herranz, Mikołaj Kocikowski, Vicki Save, Bořivoj Vojtěšek, Mark Johan Arends, Ted R. Hupp, Javier A. Alfaro

The paper identifies GPA33 as an EAC-specific biomarker and reveals post-transcriptional regulation of protein expression in EAC through multi-omics integration.

medRxiv · Nov 24, 2022 · PreprintGenetic & Genomic Medicine

Domino-like Effect of C112R Mutation on APOE4 Aggregation and Its Reduction by Alzheimer's Disease Drug Candidate

Michal Nemergut, Sérgio M. Marques, Lukáš Uhrík, Tereza Váňová, Markéta Nezvedová, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonín Kunka, Anthony Legrand, Hana Hříbková, Veronika Pospíšilová, Jiří Sedmík, , Martin Marek

The paper investigates how the C112R mutation in ApoE4 causes aggregation and shows that tramiprosate reduces this aggregation.

bioRxiv · Oct 9, 2022 · PreprintNeuroscience