Chemotherapy-treated breast cancer cells activate the Wnt signaling pathway to enter a diapause-DTP state.
Youssef El Laithy, Willy Antoni Abreu De Oliveira, Anirudh Pabba, Alessandra Qualizza, François Richard, Paraskevi Athanasouli, Carla Rios Luci, Wout De Wispelaere, Larissa Mourao, Siân Hamer, Stijn Moens, Anchel De Jaime-Soguero, Maria Francesca Baietti, Stefan J Hutten, Jos Jonkers, , Frederic Lluis
This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.
bioRxiv · Mar 8, 2024 · PreprintCancer Biology