W. Seth Childers

This study characterizes the physico-chemical properties of ParB-parS condensates and their mechanical response, suggesting a mechanism for bacterial chromosome segregation.

The paper shows bacterial ribonucleoprotein bodies (BR-bodies) maintain an acidic pH environment, enhancing enzyme activity and suggesting pH regulation as a mechanism for RNA processing.

This study identifies CsdA as the first NAD+ cap reader protein in E. coli, showing it binds NAD+ capped RNA and enhances decapping activity.

This paper designs synthetic phosphosignaling circuits in bacteria using two histidine kinases and a shared response regulator to enable multi-input signal integration and logic gate behaviors.

This study shows BR-bodies in Caulobacter crescentus help the bacteria survive copper stress by changing their structure and protecting enzymes through metal binding.

This study shows how the bacterial scaffolding protein PodJ regulates the histidine kinase PleC through phase separation, affecting its activity and localization in Caulobacter crescentus.

The paper develops a biosensor for detecting indole-3-aldehyde (I3A) using a synthetic biology approach in E. coli, demonstrating high specificity in a range of 0.1-10 µM.

The paper identifies a regulatory circuit involving scaffold proteins that coordinates cell polarity and asymmetric division in Caulobacter crescentus.

This study identifies RNase E in Caulobacter crescentus as forming liquid-liquid phase separated RNP bodies, similar to eukaryotic P-bodies, which enhance stress response and mRNA degradation.