Author

Christian Biertümpfel

National Institutes of HealthORCID 0000-0002-7528-6547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Assay:electronic health records· 1 Assay:imaging· 1

Frequent Co-Authors

Naoko MizunoiD· 3 shared Jason A. PfisteriD· 2 shared Kevin F. O’ConnelliD· 2 shared Lorenzo AgostiniiD· 2 shared Nirakar BasnetiD· 2 shared Aurélien Perrier· 1 shared Hana NedozrálováiD· 1 shared Iosune IbiricuiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

Naoko MizunoORCID

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3 papers

Recent·Most cited

Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance

Lorenzo Agostini, Jason A. Pfister, Nirakar Basnet, Jienyu Ding, Rui Zhang, Christian Biertümpfel, Kevin F. O’Connell, Naoko Mizuno

This study determines the cryo-EM structure of SSNA-1 and shows its self-assembly and microtubule-binding role in centriole maintenance and embryonic viability.

Nature Communications · Aug 13, 2025Peer-reviewedCell Biology

The C. elegans homolog of Sjögrens Syndrome Nuclear Antigen 1 is required for the structural integrity of the centriole and bipolar mitotic spindle assembly

Jason A. Pfister, Lorenzo Agostini, Lorène Bournonville, Aurélien Perrier, Prabhu Sankaralingam, Zachary G. Bell, Virginie Hamel, Paul Guichard, Christian Biertümpfel, Naoko Mizuno, Kevin F. O’Connell

This study identifies SSNA-1 as a centriole constituent required for structural integrity and bipolar spindle assembly in C. elegans.

Nature Communications · Jun 5, 2025Peer-reviewedCell Biology

In situ cryo-electron tomography reveals local cellular machineries for axon branch development

Hana Nedozrálová, Nirakar Basnet, Iosune Ibiricu, Satish Bodakuntla, Christian Biertümpfel, Naoko Mizuno

The paper uses cryo-electron tomography to visualize axon branch development in mouse neurons, revealing localized organelle and cytoskeleton dynamics and local protein synthesis at branches.

The Journal of Cell Biology · Feb 1, 2022Peer-reviewedNeuroscience